Baseline-dependent effect of dopamine's precursor L-tyrosine on working memory gating but not updating.

ABSTRACT: Adaptive goal-directed behavior requires a dynamic balance between maintenance and updating within working memory (WM). This balance is controlled by an input-gating mechanism implemented by dopamine in the basal ganglia. Given that dopaminergic manipulations can modulate performance on WM-related tasks, it is important to gain mechanistic insight into whether such manipulations differentially affect updating (i.e., encoding and removal) and the closely-related gate opening/closing processes that respectively enable/prevent updating. To clarify this issue, 2.0 g of dopamine's precursor L-tyrosine was administered to healthy young adults (N = 45) in a double-blind, placebo-controlled, within-subjects study. WM processes were empirically distinguished using the reference-back paradigm, which

SUBMITTER: Jongkees BJ 

PROVIDER: S-EPMC7266860 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature