Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC7266936 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Zhang Hui H Gan Wen-Ting WT Hao Wen-Ge WG Wang Peng-Fei PF Li Zhuo-Yan ZY Chang Lung-Ji LJ
Frontiers in oncology 20200527
Secondary acute myeloid leukemia (sAML) is a high-risk AML evolving from heterogenous prior hematological disorders. Compared to de novo AML, sAML has even worse responses to current therapy and thus is associated with lower remission rates, inferior overall survival (OS) and higher relapse rates. Many efforts have been devoted to improving the overall but with limited success, and novel strategy is thus highly needed. Recent research has identified that CLL1 is highly expressed on AML leukemia ...[more]