Ontology highlight
ABSTRACT:
SUBMITTER: van der Lelij P
PROVIDER: S-EPMC7266993 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
van der Lelij Petra P Newman Joseph A JA Lieb Simone S Jude Julian J Katis Vittorio V Hoffmann Thomas T Hinterndorfer Matthias M Bader Gerd G Kraut Norbert N Pearson Mark A MA Peters Jan-Michael JM Zuber Johannes J Gileadi Opher O Petronczki Mark M
Life science alliance 20200528 7
The cohesin subunit <i>STAG2</i> has emerged as a recurrently inactivated tumor suppressor in human cancers. Using candidate approaches, recent studies have revealed a synthetic lethal interaction between <i>STAG2</i> and its paralog <i>STAG1</i> To systematically probe genetic vulnerabilities in the absence of STAG2, we have performed genome-wide CRISPR screens in isogenic cell lines and identified STAG1 as the most prominent and selective dependency of STAG2-deficient cells. Using an inducible ...[more]