Ontology highlight
ABSTRACT:
SUBMITTER: Gao S
PROVIDER: S-EPMC7267745 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Gao Shangze S Wake Hidenori H Sakaguchi Masakiyo M Wang Dengli D Takahashi Youhei Y Teshigawara Kiyoshi K Zhong Hui H Mori Shuji S Liu Keyue K Takahashi Hideo H Nishibori Masahiro M
iScience 20200518 6
High-mobility group box-1 (HMGB1) protein has been postulated to play a pathogenic role in severe sepsis. Histidine-rich glycoprotein (HRG), a 75 kDa plasma protein, was demonstrated to improve the survival rate of septic mice through the regulation of neutrophils and endothelium barrier function. As the relationship of HRG and HMGB1 remains poorly understood, we investigated the effects of HRG on HMGB1-mediated pathway in endothelial cells, focusing on the involvement of specific receptors for ...[more]