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SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility.


ABSTRACT: The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-CoV-2 data in relation to analyses of semen and testicular tissue without appropriate controls. This article critically analyses the evidence so far on this, and the possible implications. The limitations of diagnostic tests in both sampling and testing methodologies, their validation and their relevance in interpreting data are also highlighted.

SUBMITTER: Bahadur G 

PROVIDER: S-EPMC7267791 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility.

Bahadur Gulam G   Acharya Santanu S   Muneer Asif A   Huirne Judith J   Łukaszuk Mariusz M   Doreski Pablo Alexis PA   Homburg Roy R  

Reproductive biomedicine online 20200603 3


The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-CoV-2 data in relation to analyses of semen and testicular tissue without appropriate controls. This article critically analyses the evidence so far on this, and the possible implica  ...[more]

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