Functional-structural relationship in large-scale brain networks of patients with end stage renal disease after kidney transplantation: A longitudinal study.

ABSTRACT: It is unclear how the brain network changed after kidney transplantation (KT). We explored the patterns of large-scale complex network after KT in end-stage renal disease (ESRD) patients with resting-state functional MRI (rs-fMRI) and diffusion tensor imaging (DTI). Twenty-one ESRD patients (14 men; mean age, 31.5?±?9.9?years) scheduled for KT and 17 age- and gender-matched healthy controls (HC) (8 men; mean age, 28.9?±?7.2?years) were enrolled in this study. Each participant underwent rs-fMRI and DTI scans in three time points (pre-KT, 1 and 6 months after KT [for ESRD]). Graph theory analysis was used to characterize the topological properties by using functional and structural network connectivities intergroup correlation analysis was performed between functional/structural MR indexes and clinical markers. Compared with HC, pre-KT ESRD patients showed an altered topological organization in both functional and structural networks. Compared with pre-KT, increased node degree and node efficiency were observed for both functional and structural networks at 1 month after KT (all p?

SUBMITTER: Chen HJ 

PROVIDER: S-EPMC7268055 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature