Ontology highlight
ABSTRACT:
SUBMITTER: Alvarez-Prats A
PROVIDER: S-EPMC7268203 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Alvarez-Prats Alejandro A Bjelobaba Ivana I Aldworth Zane Z Baba Takashi T Abebe Daniel D Kim Yeun Ju YJ Stojilkovic Stanko S SS Stopfer Mark M Balla Tamas T
Cell reports 20180601 10
Active membrane remodeling during myelination relies on phospholipid synthesis and membrane polarization, both of which are known to depend on inositol phospholipids. Here, we show that sciatic nerves of mice lacking phosphatidylinositol 4-kinase alpha (PI4KA) in Schwann cells (SCs) show substantially reduced myelin thickness with grave consequences on nerve conductivity and motor functions. Surprisingly, prolonged inhibition of PI4KA in immortalized mouse SCs failed to decrease plasma membrane ...[more]