Ontology highlight
ABSTRACT:
SUBMITTER: Cao H
PROVIDER: S-EPMC7268388 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Cao Huynh H Xiao Jeffrey J Reeves Mark E ME Payne Kimberly K Chen Chien Shing CS Baylink David J DJ Marcucci Guido G Xu Yi Y
Journal of hematology & oncology 20200603 1
Here, we report a unique acute myeloid leukemia (AML) bone marrow-derived mesenchymal stem cell (MSC) with both mesenchymal and endothelial potential, which we have named Mesenchymal Cancer Stem Cells (MCSCs). These MCSCs are CD90-CD13-CD44+ and differ from MSCs in isolation, expansion, differentiation, immunophenotype, and cytokine release profile. Furthermore, blocking CD44 inhibited the proliferation and cluster formation of early MCSCs with lower ICAM-1 protein levels. Similar CD90-CD44+ can ...[more]