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ABSTRACT: Background
The decision of transarterial chemoembolization (TACE) initiation and/or repetition remains challenging in patients with unresectable hepatocellular carcinoma (HCC). The aim was to develop a prognostic scoring system to guide TACE initiation/repetition.Methods
A total of 597 consecutive patients who underwent TACE as their initial treatment for unresectable HCC were included. We derived a prediction model using independent risk factors for overall survival (OS), which was externally validated in an independent cohort (n?=?739).Results
Independent risk factors of OS included Albumin-bilirubin (ALBI) grade, maximal tumor size, alpha-fetoprotein, and tumor response to initial TACE, which were used to develop a scoring system ("ASAR"). C-index values for OS were 0.733 (95% confidence interval [CI]?=?0.570-0.871) in the derivation, 0.700 (95% CI?=?0.445-0.905) in the internal validation, and 0.680 (95% CI?=?0.652-0.707) in the external validation, respectively. Patients with ASARConclusionsASAR provides refined prognostication for repetition of TACE in patients with unresectable HCC. For Child-Pugh class B patients, a modified model with baseline factors might guide TACE initiation.
SUBMITTER: Nam JY
PROVIDER: S-EPMC7268402 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nam Joon Yeul JY Choe A Reum AR Sinn Dong Hyun DH Lee Jeong-Hoon JH Kim Hwi Young HY Yu Su Jong SJ Kim Yoon Jun YJ Yoon Jung-Hwan JH Lee Jeong Min JM Chung Jin Wook JW Choi Sun Young SY Lee Jeong Kyong JK Baek Seung Yon SY Lee Hye Ah HA Kim Tae Hun TH Yoo Kwon K
BMC cancer 20200601 1
<h4>Background</h4>The decision of transarterial chemoembolization (TACE) initiation and/or repetition remains challenging in patients with unresectable hepatocellular carcinoma (HCC). The aim was to develop a prognostic scoring system to guide TACE initiation/repetition.<h4>Methods</h4>A total of 597 consecutive patients who underwent TACE as their initial treatment for unresectable HCC were included. We derived a prediction model using independent risk factors for overall survival (OS), which ...[more]