Ontology highlight
ABSTRACT:
SUBMITTER: Hua H
PROVIDER: S-EPMC7268628 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Journal of hematology & oncology 20200603 1
Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in cancer. However, clinical trials of the type I IGF receptor (IGF-IR)-targeted agents have been largely disappointing. Accumulating evidence demonstrates that the IGF axis not only promotes tumorigenesis, but also confers resistance to standard treatm ...[more]