Dataset Information

Structured decision-making drives guidelines panels' recommendations "for" but not "against" health interventions.

ABSTRACT:

Background and objectives

The determinants of guideline panels' recommendations remain uncertain. The objective of this study was to investigate factors considered by members of 8 panels convened by the American Society of Hematology (ASH) to develop guidelines using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system.

Study design and setting

Web-based survey of the participants in the ASH guidelines panels.

Analysis

two-level hierarchical, random-effect, multivariable regression analysis to explore the relation between GRADE and non-GRADE factors and strength of recommendations (SOR).

Results

In the primary analysis, certainty in evidence [OR = 1.83; (95CI% 1.45-2.31)], balance of benefits and harms [OR = 1.49 (95CI% 1.30-1.69)] and variability in patients' values and preferences [OR = 1.47 (95CI% 1.15-1.88)] proved the strongest predictors of SOR. In a secondary analysis, certainty of evidence was associated with a strong recommendation [OR = 3.60 (95% CI 2.16-6.00)] when panel members recommended "for" interventions but not when they made recommendations "against" interventions [OR = 0.98 (95%CI: 0.57-1.8)] consistent with "yes" bias. Agreement between individual members and the group in rating SOR varied (kappa ranged from -0.01 to 0.64).

Conclusion

GRADE's conceptual framework proved, in general, to be highly associated with SOR. Failure of certainty of evidence to be associated with SOR against an intervention, suggest the need for improvements in the process.

SUBMITTER: Djulbegovic B

PROVIDER: S-EPMC7268742 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Publications

Structured decision-making drives guidelines panels' recommendations "for" but not "against" health interventions.

Djulbegovic Benjamin B Reljic Tea T Elqayam Shira S Cuker Adam A Hozo Iztok I Zhou Qi Q Li Shelly-Anne SA Alexander Paul P Nieuwlaat Robby R Wiercioch Wojtek W Schünemann Holger H Guyatt Gordon G

Journal of clinical epidemiology 20190216

<h4>Background and objectives</h4>The determinants of guideline panels' recommendations remain uncertain. The objective of this study was to investigate factors considered by members of 8 panels convened by the American Society of Hematology (ASH) to develop guidelines using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system.<h4>Study design and setting</h4>Web-based survey of the participants in the ASH guidelines panels.<h4>Analysis</h4>two-level hierarchical, ra ...[more]

PMID: 30779950

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Dataset Information

Structured decision-making drives guidelines panels' recommendations "for" but not "against" health interventions.

Background and objectives

Study design and setting

Analysis

Results

Conclusion

Publications

Structured decision-making drives guidelines panels' recommendations "for" but not "against" health interventions.

Similar Datasets

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