Ontology highlight
ABSTRACT:
SUBMITTER: Lobry T
PROVIDER: S-EPMC7269416 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Lobry Tatiana T Miller Roy R Nevo Nathalie N Rocca Celine J CJ Zhang Jinzhong J Catz Sergio D SD Moore Fiona F Thomas Lucie L Pouly Daniel D Bailleux Anne A Guerrera Ida Chiara IC Gubler Marie-Claire MC Cheung Wai W WW Mak Robert H RH Montier Tristan T Antignac Corinne C Cherqui Stephanie S
Kidney international 20190306 2
Inflammation is involved in the pathogenesis of many disorders. However, the underlying mechanisms are often unknown. Here, we test whether cystinosin, the protein involved in cystinosis, is a critical regulator of galectin-3, a member of the β-galactosidase binding protein family, during inflammation. Cystinosis is a lysosomal storage disorder and, despite ubiquitous expression of cystinosin, the kidney is the primary organ impacted by the disease. Cystinosin was found to enhance lysosomal loca ...[more]