Ontology highlight
ABSTRACT:
SUBMITTER: Sebastianutto I
PROVIDER: S-EPMC7269571 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20200301 3
Dopamine receptor D1 modulates glutamatergic transmission in cortico-basal ganglia circuits and represents a major target of L-DOPA therapy in Parkinson's disease. Here we show that D1 and metabotropic glutamate type 5 (mGlu5) receptors can form previously unknown heteromeric entities with distinctive functional properties. Interacting with Gq proteins, cell-surface D1-mGlu5 heteromers exacerbated PLC signaling and intracellular calcium release in response to either glutamate or dopamine. In rod ...[more]