Ontology highlight
ABSTRACT:
SUBMITTER: Gerstmans H
PROVIDER: S-EPMC7269649 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Gerstmans H H Grimon D D Gutiérrez D D Lood C C Rodríguez A A van Noort V V Lammertyn J J Lavigne R R Briers Y Y
Science advances 20200603 23
Health care authorities are calling for new antibacterial therapies to cope with the global emergence of antibiotic-resistant bacteria. Bacteriophage-encoded lysins are a unique class of antibacterials with promising (pre)clinical progress. Custom engineering of lysins allows for the creation of variants against potentially any bacterial pathogen. We here present a high-throughput hit-to-lead development platform for engineered lysins. The platform is driven by VersaTile, a new DNA assembly meth ...[more]