Ontology highlight
ABSTRACT:
SUBMITTER: Delgado I
PROVIDER: S-EPMC7269661 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Delgado Irene I López-Delgado Alejandra C AC Roselló-Díez Alberto A Giovinazzo Giovanna G Cadenas Vanessa V Fernández-de-Manuel Laura L Sánchez-Cabo Fátima F Anderson Matthew J MJ Lewandoski Mark M Torres Miguel M
Science advances 20200603 23
The positional information theory proposes that a coordinate system provides information to embryonic cells about their position and orientation along a patterning axis. Cells interpret this information to produce the appropriate pattern. During development, morphogens and interpreter transcription factors provide this information. We report a gradient of Meis homeodomain transcription factors along the mouse limb bud proximo-distal (PD) axis antiparallel to and shaped by the inhibitory action o ...[more]