Ontology highlight
ABSTRACT:
SUBMITTER: Dhani NC
PROVIDER: S-EPMC7269808 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Dhani Neesha C NC Hirte Hal W HW Wang Lisa L Burnier Julia V JV Jain Angela A Butler Marcus O MO Welch Stephen S Fleming Gini F GF Hurteau Jean J Matsuo Koji K Matei Daniela D Jimenez Waldo W Johnston Carolyn C Cristea Mihaela M Tonkin Katia K Ghatage Prafull P Lheureux Stephanie S Mehta Anjali A Quintos Judy J Tan Qian Q Kamel-Reid Suzanne S Ludkovski Olga O Tsao Ming-Sound MS Wright John J JJ Oza Amit M AM
Clinical cancer research : an official journal of the American Association for Cancer Research 20200128 11
<h4>Purpose</h4>The relevance of the MET/hepatocyte growth factor pathway in endometrial cancer tumor biology supports the clinical evaluation of cabozantinib in this disease.<h4>Patients and methods</h4>PHL86/NCI#9322 (NCT01935934) is a single arm study that evaluated cabozantinib (60 mg once daily) in women with endometrial cancer with progression after chemotherapy. Coprimary endpoints were response rate and 12-week progression-free-survival (PFS). Patients with uncommon histology endometrial ...[more]