Ontology highlight
ABSTRACT:
SUBMITTER: Kotsopoulos J
PROVIDER: S-EPMC7269832 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Kotsopoulos Joanne J McGee Emma E EE Lozano-Esparza Susana S Garber Judy E JE Ligibel Jennifer J Collins Laura C LC Polyak Kornelia K Brown Myles M Narod Steven S Tamimi Rulla M RM Eliassen A Heather AH
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20200410 6
<h4>Background</h4>Emerging evidence supports a role of the receptor activator of NF-κB (RANK) pathway in normal mammary gland development and breast carcinogenesis. Osteoprotegerin (OPG) is the endogenous decoy receptor for RANK-ligand (RANKL), which inhibits RANK-signaling. Whether OPG may be a biomarker of breast cancer risk remains unclear.<h4>Methods</h4>We evaluated the association between plasma OPG and breast cancer risk in a case (<i>n</i> = 297)-control (<i>n</i> = 297) study nested wi ...[more]