Ontology highlight
ABSTRACT:
SUBMITTER: Friedemann M
PROVIDER: S-EPMC7270080 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Friedemann Markus M Gutewort Katharina K Thiem Dana D Nacke Brit B Jandeck Carsten C Lange Björn Sönke BS Sukocheva Olga O Suttorp Meinolf M Menschikowski Mario M
Scientific reports 20200603 1
Acute lymphoblastic leukaemia (ALL) is the most common form of paediatric cancer and epigenetic aberrations are determinants of leukaemogenesis. The aim of this study was to investigate the methylation degree of a distinct phospholipase A2 receptor 1 (PLA2R1) promoter region in paediatric ALL patients and to evaluate its relevance as new biomarker for monitoring treatment response and burden of residual disease. The impact of PLA2R1 re-expression on proliferative parameters was assessed in vitro ...[more]