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A glioneuronal tumor with CLIP2-MET fusion.

ABSTRACT: We report a case of glioneuronal tumor (GNT) with a discovery of novel gene fusion of CLIP2-MET resulting from aberrant chromosome 7 abnormalities. We executed an elaborate genomic study on this case including whole-exome sequencing and RNA sequencing. Genomic analysis of the tumor revealed aberrations in chromosomes 1 and 7 and a CLIP2-MET fusion. Further analysis of the upregulated genes revealed substantial connections with MAPK pathway activation. We concluded that the chromosome 7 abnormalities prompted CLIP2-MET gene fusion which successively leads to MAPK pathway activation. We deliberated that MAPK pathway activation is one of the driver pathways responsible for the oncogenesis of GNT.

SUBMITTER: Chowdhury T 

PROVIDER: S-EPMC7270112 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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We report a case of glioneuronal tumor (GNT) with a discovery of novel gene fusion of <i>CLIP2-MET</i> resulting from aberrant chromosome 7 abnormalities. We executed an elaborate genomic study on this case including whole-exome sequencing and RNA sequencing. Genomic analysis of the tumor revealed aberrations in chromosomes 1 and 7 and a <i>CLIP2-MET</i> fusion. Further analysis of the upregulated genes revealed substantial connections with MAPK pathway activation. We concluded that the chromoso  ...[more]

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