Ontology highlight
ABSTRACT:
SUBMITTER: Omichi R
PROVIDER: S-EPMC7270144 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Omichi Ryotaro R Yoshimura Hidekane H Shibata Seiji B SB Vandenberghe Luk H LH Smith Richard J H RJH
Molecular therapy. Methods & clinical development 20200513
Gene delivery is a key component for the treatment of genetic hearing loss. To date, a myriad of adeno-associated virus (AAV) serotypes and surgical approaches have been employed to deliver transgenes to cochlear hair cells, but the efficacy of dual transduction remains unclear. Herein, we investigated cellular tropism of single injections of AAV serotype 1 (AAV1), AAV2, AAV8, AAV9, and Anc80L65, and quantitated dual-vector co-transduction rates following co-injection of AAV2 and AAV9 vectors in ...[more]