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Molecular characterisation of ILRUN, a novel inhibitor of proinflammatory and antimicrobial cytokines.


ABSTRACT: Regulation of type-I interferon (IFN) production is essential to the balance between antimicrobial defence and autoimmune disorders. The human protein-coding gene ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains, previously C6orf106) was recently characterised as an inhibitor of antiviral and proinflammatory cytokine (interferon-alpha/beta and tumor necrosis factor alpha) transcription. Currently there is a paucity of information about the molecular characteristics of ILRUN, despite it being associated with several diseases including virus infection, coronary artery disease, obesity and cancer. Here, we characterise ILRUN as a highly phylogenetically conserved protein containing UBA-like and a NBR1-like domains that are both essential for inhibition of type-I interferon and tumor necrosis factor alpha) transcription in human cells. We also solved the crystal structure of the NBR1-like domain, providing insights into its potential role in ILRUN function. This study provides critical information for future investigations into the role of ILRUN in health and disease.

SUBMITTER: Ambrose RL 

PROVIDER: S-EPMC7270589 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Molecular characterisation of ILRUN, a novel inhibitor of proinflammatory and antimicrobial cytokines.

Ambrose Rebecca L RL   Brice Aaron M AM   Brice Aaron M AM   Caputo Alessandro T AT   Alexander Marina R MR   Tribolet Leon L   Liu Yu Chih YC   Adams Timothy E TE   Bean Andrew G D AGD   Stewart Cameron R CR  

Heliyon 20200603 6


Regulation of type-I interferon (IFN) production is essential to the balance between antimicrobial defence and autoimmune disorders. The human protein-coding gene ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains, previously C6orf106) was recently characterised as an inhibitor of antiviral and proinflammatory cytokine (interferon-alpha/beta and tumor necrosis factor alpha) transcription. Currently there is a paucity of information about the molecular characteristics of  ...[more]

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