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Lewis Acid-Catalyzed Enantioselective Friedel-Crafts Alkylation of Pyrrole in Water.

ABSTRACT: Highly enantioselective Friedel-Crafts alkylation of pyrroles with 2-enoyl-pyridine N-oxides in water/chloroform (10:1) was developed under catalysis of Lewis acid. The Friedel-Crafts alkylation products can be obtained in high yields and excellent enantioselectivities. Moreover, several control experiments were carried out to study the reaction mechanism.

SUBMITTER: Sun J

PROVIDER: S-EPMC7271029 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Lewis Acid-Catalyzed Enantioselective Friedel-Crafts Alkylation of Pyrrole in Water.

Sun Jianan J Gui Yang Y Huang Yekai Y Li Jindong J Zha Zhenggen Z Yang Yu Y Wang Zhiyong Z

ACS omega 20200511 21

Highly enantioselective Friedel-Crafts alkylation of pyrroles with 2-enoyl-pyridine N-oxides in water/chloroform (10:1) was developed under catalysis of Lewis acid. The Friedel-Crafts alkylation products can be obtained in high yields and excellent enantioselectivities. Moreover, several control experiments were carried out to study the reaction mechanism. ...[more]

PMID: 32548375

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