Ontology highlight
ABSTRACT:
SUBMITTER: Martone J
PROVIDER: S-EPMC7271651 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Martone Julie J Mariani Davide D Santini Tiziana T Setti Adriano A Shamloo Sama S Colantoni Alessio A Capparelli Francesca F Paiardini Alessandro A Dimartino Dacia D Morlando Mariangela M Bozzoni Irene I
EMBO reports 20200426 6
Guanine-quadruplexes (G4) included in RNA molecules exert several functions in controlling gene expression at post-transcriptional level; however, the molecular mechanisms of G4-mediated regulation are still poorly understood. Here, we describe a regulatory circuitry operating in the early phases of murine muscle differentiation in which a long non-coding RNA (SMaRT) base pairs with a G4-containing mRNA (Mlx-γ) and represses its translation by counteracting the activity of the DHX36 RNA helicase ...[more]