Ontology highlight
ABSTRACT:
SUBMITTER: Jung J
PROVIDER: S-EPMC7271819 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Jung Jewon J Venkatachalam Kartik K
Cell calcium 20191001
To thrive in otherwise inhospitable conditions, cancer cells utilize endolysosomes to impose homeostatic control over cellular metabolism and growth. In a recent study, Kasitinon et al. demonstrate a requirement for the endolysosomal channel, TRPML1, in proliferation and survival of melanoma cells. This study adds to a growing list of cancers that exhibit selective vulnerability to the loss of TRPML1. ...[more]