TRPing the homeostatic alarm - Melanoma cells are selectively vulnerable to TRPML1 deletion.
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ABSTRACT:
SUBMITTER: Jung J
PROVIDER: S-EPMC7271819 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
TRPing the homeostatic alarm - Melanoma cells are selectively vulnerable to TRPML1 deletion.
Jung Jewon J Venkatachalam Kartik K
Cell calcium 20191001
To thrive in otherwise inhospitable conditions, cancer cells utilize endolysosomes to impose homeostatic control over cellular metabolism and growth. In a recent study, Kasitinon et al. demonstrate a requirement for the endolysosomal channel, TRPML1, in proliferation and survival of melanoma cells. This study adds to a growing list of cancers that exhibit selective vulnerability to the loss of TRPML1. ...[more]
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