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TRPing the homeostatic alarm - Melanoma cells are selectively vulnerable to TRPML1 deletion.


ABSTRACT: To thrive in otherwise inhospitable conditions, cancer cells utilize endolysosomes to impose homeostatic control over cellular metabolism and growth. In a recent study, Kasitinon et al. demonstrate a requirement for the endolysosomal channel, TRPML1, in proliferation and survival of melanoma cells. This study adds to a growing list of cancers that exhibit selective vulnerability to the loss of TRPML1.

SUBMITTER: Jung J 

PROVIDER: S-EPMC7271819 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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TRPing the homeostatic alarm - Melanoma cells are selectively vulnerable to TRPML1 deletion.

Jung Jewon J   Venkatachalam Kartik K  

Cell calcium 20191001


To thrive in otherwise inhospitable conditions, cancer cells utilize endolysosomes to impose homeostatic control over cellular metabolism and growth. In a recent study, Kasitinon et al. demonstrate a requirement for the endolysosomal channel, TRPML1, in proliferation and survival of melanoma cells. This study adds to a growing list of cancers that exhibit selective vulnerability to the loss of TRPML1. ...[more]

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