The Sensory Coding of Warm Perception.
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ABSTRACT:
SUBMITTER: Paricio-Montesinos R
PROVIDER: S-EPMC7272120 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
The Sensory Coding of Warm Perception.
Paricio-Montesinos Ricardo R Schwaller Frederick F Udhayachandran Annapoorani A Rau Florian F Walcher Jan J Evangelista Roberta R Vriens Joris J Voets Thomas T Poulet James F A JFA Lewin Gary R GR
Neuron 20200323 5
Humans detect skin temperature changes that are perceived as warm or cool. Like humans, mice report forepaw skin warming with perceptual thresholds of less than 1°C and do not confuse warm with cool. We identify two populations of polymodal C-fibers that signal warm. Warm excites one population, whereas it suppresses the ongoing cool-driven firing of the other. In the absence of the thermosensitive TRPM2 or TRPV1 ion channels, warm perception was blunted, but not abolished. In addition, trpv1:tr ...[more]
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