Needs assessment for novel Gram-negative antibiotics in US hospitals: a retrospective cohort study.

ABSTRACT:

Background

Evidence-based needs assessments for novel antibiotics against highly-resistant Gram-negative infections (GNIs) are scarce. We aimed to use real-world data from an electronic health record repository to identify treatment opportunities in US hospitals for GNIs resistant to all first-line drugs.

Methods

For this retrospective cohort study, population estimates with an unmet need for novel Gram-negative antibiotics were quantified using the Cerner Health Facts database (2009-15), aggregating episodes of infection in US hospitals with pathogens displaying difficult-to-treat resistance (DTR; resistance to carbapenems, other β-lactams, and fluoroquinolones) and episodes involving empirical coverage with reserve drugs (colistin or polymyxin B and aminoglycosides). Episo

SUBMITTER: Strich JR 

PROVIDER: S-EPMC7272178 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature