Comprehensive Analysis of Prognostic Alternative Splicing Signatures in Endometrial Cancer.

ABSTRACT:

Background

Alternative splicing (AS) is one of the critical post-transcriptional regulatory mechanisms of various cancers and also plays a crucial role in the development of cancers, including endometrial cancer (EC).

Methods

The splicing data and gene expression profiles of EC were obtained from The Cancer Genome Atlas. The corresponding clinical data were extracted from TCGA-CDR. With univariate Cox regression analysis, least absolute shrinkage and selection operator model, and multivariate Cox regression analysis, the survival-related AS events were selected. Functional enrichment analysis was also performed to investigate the functions of these AS events. Splicing factors and AS regulation network were constructed to understand the correlation among these AS events.

R

SUBMITTER: Chen P 

PROVIDER: S-EPMC7272712 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature