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Increasing the public activity cliff knowledge base with new categories of activity cliffs.

ABSTRACT: Aim:Extending the public knowledge base of activity cliffs (ACs) with new categories of ACs having special structural characteristics. Methodology:Dual-site ACs, isomer ACs and ACs with privileged substructures are described and their systematic identification is detailed. Exemplary results & data:More than 7400 new ACs belonging to different categories with activity against more than 200 targets were identified and are made publicly available. Limitations & next steps:For dual-site ACs, limited numbers of isomers are available as structural analogs for rationalizing contributions to AC formation. The search for such analogs will continue. In addition, the target distribution of ACs containing privileged substructures will be further analyzed.

SUBMITTER: Hu H

PROVIDER: S-EPMC7273365 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Increasing the public activity cliff knowledge base with new categories of activity cliffs.

Hu Huabin H Bajorath Jürgen J

Future science OA 20200415 5

<h4>Aim</h4>Extending the public knowledge base of activity cliffs (ACs) with new categories of ACs having special structural characteristics.<h4>Methodology</h4>Dual-site ACs, isomer ACs and ACs with privileged substructures are described and their systematic identification is detailed.<h4>Exemplary results & data</h4>More than 7400 new ACs belonging to different categories with activity against more than 200 targets were identified and are made publicly available.<h4>Limitations & next steps</ ...[more]

PMID: 32518687

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Project description:BackgroundUnhealthy eating behaviors are risk factors for non-communicable diseases. Parents largely influence the development of eating behaviors during childhood through their feeding practices. Parental feeding practices in line with recommendations are more likely to turn into healthier outcomes in children. From a public health perspective, it should be first ascertained whether providing parents with recommendations about child feeding is a useful approach for increase parental knowledge. Recently, the French health authorities developed a brochure covering updated child feeding recommendations. The present study aims to evaluate the short-term effects of reading this brochure on parental knowledge about child feeding, distinguishing knowledge accuracy and certainty.MethodsA brochure containing updated child feeding recommendations for 0-3 years old was developed by the French public health agency. A representative sample of French parents (n = 400) was targeted to complete an online questionnaire (T0) comprising 30 statements regarding child feeding. For each statement, parents indicated whether it was true/false and how certain they were of their answer (4-point scale). After receiving and reading the brochure, the same parents completed the same questionnaire 3 weeks later (T1). Accuracy (number of correct answers) and certainty (number of mastered answers: correct answers given with the maximal degree of certainty) were compared at T1 vs. T0 using paired t-tests. Knowledge evolution based on parental age, parity and education level was tested with linear models.ResultsA total of 452 parents responded at T0 and T1 and were considered for analysis. Between T0 and T1, the number of correct answers [median 22-25, t (451) = 17.2, p ≤ 0.001] and mastered answers [median 11-17, t (451) = 18.8, p ≤ 0.001] significantly increased. The median of the difference between T1 and T0 was larger for mastered than for correct answers. The observed evolution in knowledge was independent of parental age, parity or education level.ConclusionsA brochure containing child feeding recommendations has the potential to increase the accuracy and, to an even greater degree, the certainty of parental knowledge. This increase was observed even for younger or less educated parents.

Dataset Information

Increasing the public activity cliff knowledge base with new categories of activity cliffs.

Publications

Increasing the public activity cliff knowledge base with new categories of activity cliffs.

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