Ontology highlight
ABSTRACT:
SUBMITTER: Le TL
PROVIDER: S-EPMC7273534 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Le Thuy-Linh TL Sribudiani Yunia Y Dong Xiaomin X Huber Céline C Kois Chelsea C Baujat Geneviève G Gordon Christopher T CT Mayne Valerie V Galmiche Louise L Serre Valérie V Goudin Nicolas N Zarhrate Mohammed M Bole-Feysot Christine C Masson Cécile C Nitschké Patrick P Verheijen Frans W FW Pais Lynn L Pelet Anna A Sadedin Simon S Pugh John A JA Shur Natasha N White Susan M SM El Chehadeh Salima S Christodoulou John J Cormier-Daire Valérie V Hofstra R M W RMW Lyonnet Stanislas S Tan Tiong Yang TY Attié-Bitach Tania T Kerstjens-Frederikse Wilhelmina S WS Amiel Jeanne J Thomas Sophie S
American journal of human genetics 20200514 6
The evolutionarily conserved hedgehog (Hh) pathway is essential for organogenesis and plays critical roles in postnatal tissue maintenance and renewal. A unique feature of the vertebrate Hh pathway is that signal transduction requires the primary cilium (PC) where major pathway components are dynamically enriched. These factors include smoothened (SMO) and patched, which constitute the core reception system for sonic hedgehog (SHH) as well as GLI transcription factors, the key mediators of the p ...[more]