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Analysis of the p53 pathway in peripheral blood of retinoblastoma patients; potential biomarkers.

ABSTRACT: Loss of retinoblastoma (RB) function in the cone cells during retina development is necessary but not sufficient for retinoblastoma development. It has been reported that in the absence of RB activity, a retinoma is generated, and the onset of retina cancer occurs until the p53 pathway is altered. Unlike other types of cancer, in retinoblastoma the p53 tumour suppressor is mostly wild type, although its two primary regulators, MDMX and MDM2, are commonly dysregulated. A mutated RB form is inherited in around 35% of the cases, but normally two, somatic mutations are needed to alter the RB function. Here we investigated the mRNA levels of RB, p53, MDMX and MDM2 in peripheral blood samples of retinoblastoma patients to monitor the pathway status of p53 in somatic cells. We sought to investigate the involvement of these genes in the development of retina cancer, with the aim of identifying biomarkers for early diagnosis of this disease.

SUBMITTER: Martinez-Sanchez M

PROVIDER: S-EPMC7274427 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Analysis of the p53 pathway in peripheral blood of retinoblastoma patients; potential biomarkers.

Martínez-Sánchez Mayra M Moctezuma-Dávila Mariana M Hernandez-Monge Jesús J Rangel-Charqueño Martha M Olivares-Illana Vanesa V

PloS one 20200605 6

Loss of retinoblastoma (RB) function in the cone cells during retina development is necessary but not sufficient for retinoblastoma development. It has been reported that in the absence of RB activity, a retinoma is generated, and the onset of retina cancer occurs until the p53 pathway is altered. Unlike other types of cancer, in retinoblastoma the p53 tumour suppressor is mostly wild type, although its two primary regulators, MDMX and MDM2, are commonly dysregulated. A mutated RB form is inheri ...[more]

PMID: 32502182

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Dataset Information

Analysis of the p53 pathway in peripheral blood of retinoblastoma patients; potential biomarkers.

Publications

Analysis of the p53 pathway in peripheral blood of retinoblastoma patients; potential biomarkers.

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