Ontology highlight
ABSTRACT:
SUBMITTER: Schaich MA
PROVIDER: S-EPMC7274783 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Schaich Matthew A MA Sanford Samantha L SL Welfer Griffin A GA Johnson Samuel A SA Khoang Thu H TH Opresko Patricia L PL Freudenthal Bret D BD
eLife 20200605
Telomerase extends telomere sequences at chromosomal ends to protect genomic DNA. During this process it must select the correct nucleotide from a pool of nucleotides with various sugars and base pairing properties, which is critically important for the proper capping of telomeric sequences by shelterin. Unfortunately, how telomerase selects correct nucleotides is unknown. Here, we determined structures of <i>Tribolium castaneum</i> telomerase reverse transcriptase (TERT) throughout its catalyti ...[more]