MutSpot: detection of non-coding mutation hotspots in cancer genomes.

ABSTRACT: Recurrence and clustering of somatic mutations (hotspots) in cancer genomes may indicate positive selection and involvement in tumorigenesis. MutSpot performs genome-wide inference of mutation hotspots in non-coding and regulatory DNA of cancer genomes. MutSpot performs feature selection across hundreds of epigenetic and sequence features followed by estimation of position- and patient-specific background somatic mutation probabilities. MutSpot is user-friendly, works on a standard workstation, and scales to thousands of cancer genomes.

SUBMITTER: Guo YA 

PROVIDER: S-EPMC7275039 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature