MutSpot: detection of non-coding mutation hotspots in cancer genomes.
Ontology highlight
ABSTRACT:
SUBMITTER: Guo YA
PROVIDER: S-EPMC7275039 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
MutSpot: detection of non-coding mutation hotspots in cancer genomes.
Guo Yu Amanda YA Chang Mei Mei MM Skanderup Anders Jacobsen AJ
NPJ genomic medicine 20200605
Recurrence and clustering of somatic mutations (hotspots) in cancer genomes may indicate positive selection and involvement in tumorigenesis. MutSpot performs genome-wide inference of mutation hotspots in non-coding and regulatory DNA of cancer genomes. MutSpot performs feature selection across hundreds of epigenetic and sequence features followed by estimation of position- and patient-specific background somatic mutation probabilities. MutSpot is user-friendly, works on a standard workstation, ...[more]
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