Ontology highlight
ABSTRACT:
SUBMITTER: Yan Q
PROVIDER: S-EPMC7275040 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Yan Qi Q Zhu Kai K Zhang Lu L Fu Qiang Q Chen Zhaowei Z Liu Shan S Fu Dou D Nakazato Ryota R Yoshioka Katsuji K Diao Bo B Ding Guohua G Li Xiaogang X Wang Huiming H Wang Huiming H
Communications biology 20200605 1
Renal fibrosis is controlled by profibrotic and antifibrotic forces. Exploring anti-fibrosis factors and mechanisms is an attractive strategy to prevent organ failure. Here we identified the JNK-associated leucine zipper protein (JLP) as a potential endogenous antifibrotic factor. JLP, predominantly expressed in renal tubular epithelial cells (TECs) in normal human or mouse kidneys, was downregulated in fibrotic kidneys. Jlp deficiency resulted in more severe renal fibrosis in unilateral uretera ...[more]