Reverse engineering synthetic antiviral amyloids.
Ontology highlight
ABSTRACT:
SUBMITTER: Michiels E
PROVIDER: S-EPMC7275043 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Reverse engineering synthetic antiviral amyloids.
Michiels Emiel E Roose Kenny K Gallardo Rodrigo R Khodaparast Ladan L Khodaparast Laleh L van der Kant Rob R Siemons Maxime M Houben Bert B Ramakers Meine M Wilkinson Hannah H Guerreiro Patricia P Louros Nikolaos N Kaptein Suzanne J F SJF Ibañez Lorena Itatí LI Smet Anouk A Baatsen Pieter P Liu Shu S Vorberg Ina I Bormans Guy G Neyts Johan J Saelens Xavier X Rousseau Frederic F Schymkowitz Joost J
Nature communications 20200605 1
Human amyloids have been shown to interact with viruses and interfere with viral replication. Based on this observation, we employed a synthetic biology approach in which we engineered virus-specific amyloids against influenza A and Zika proteins. Each amyloid shares a homologous aggregation-prone fragment with a specific viral target protein. For influenza we demonstrate that a designer amyloid against PB2 accumulates in influenza A-infected tissue in vivo. Moreover, this amyloid acts specifica ...[more]
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