Ontology highlight
ABSTRACT:
SUBMITTER: Yuan F
PROVIDER: S-EPMC7275074 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Yuan Feixiang F Jiang Haizhou H Yin Hanrui H Jiang Xiaoxue X Jiao Fuxin F Chen Shanghai S Ying Hao H Chen Yan Y Zhai Qiwei Q Guo Feifan F
Nature communications 20200605 1
The browning of white adipose tissue (WAT) has got much attention for its potential beneficial effects on metabolic disorders, however, the nutritional factors and neuronal signals involved remain largely unknown. We sought to investigate whether WAT browning is stimulated by leucine deprivation, and whether the amino acid sensor, general control non-derepressible 2 (GCN2), in amygdalar protein kinase C-δ (PKC-δ) neurons contributes to this regulation. Our results show that leucine deficiency ca ...[more]