Ontology highlight
ABSTRACT:
SUBMITTER: Wu P
PROVIDER: S-EPMC7275230 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wu Peng P Yu Ting T Wu Jun J Chen Junfeng J
BioMed research international 20200527
Licochalcone A (LCA) exhibited anticancer activity through modulating reactive oxygen species (ROS) levels in some cancer cells and has been evidenced to suppress colorectal cancer (CRC) formation and progression. However, whether LCA mediates the progression of CRC by regulating ROS production remains unclear. To address this, HCT-116 cells were treated with LCA, resulting in G0/G1 phase arrest, apoptosis, and high ROS generation, which were attenuated by N-acetyl-L-cysteine, a ROS inhibitor. I ...[more]