Ontology highlight
ABSTRACT:
SUBMITTER: Machhi J
PROVIDER: S-EPMC7275301 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Machhi Jatin J Kevadiya Bhavesh D BD Muhammad Ijaz Khan IK Herskovitz Jonathan J Olson Katherine E KE Mosley R Lee RL Gendelman Howard E HE
Molecular neurodegeneration 20200605 1
Emerging evidence demonstrates that adaptive immunity influences the pathobiology of neurodegenerative disorders. Misfolded aggregated self-proteins can break immune tolerance leading to the induction of autoreactive effector T cells (Teffs) with associated decreases in anti-inflammatory neuroprotective regulatory T cells (Tregs). An imbalance between Teffs and Tregs leads to microglial activation, inflammation and neuronal injury. The cascade of such a disordered immunity includes the drainage ...[more]