Ontology highlight
ABSTRACT:
SUBMITTER: Damaschke NA
PROVIDER: S-EPMC7275597 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Damaschke Nathan A NA Gawdzik Joseph J Avilla Mele M Yang Bing B Svaren John J Roopra Avtar A Luo Jian-Hua JH Yu Yan P YP Keles Sunduz S Jarrard David F DF
Clinical epigenetics 20200605 1
<h4>Background</h4>The chromatin insulator CCCTC-binding factor (CTCF) displays tissue-specific DNA binding sites that regulate transcription and chromatin organization. Despite evidence linking CTCF to the protection of epigenetic states through barrier insulation, the impact of CTCF loss on genome-wide DNA methylation sites in human cancer remains undefined.<h4>Results</h4>Here, we demonstrate that prostate and breast cancers within The Cancer Genome Atlas (TCGA) exhibit frequent copy number l ...[more]