Ontology highlight
ABSTRACT:
SUBMITTER: Chagoya G
PROVIDER: S-EPMC7275784 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Chagoya Gustavo G Kwatra Shawn G SG Nanni Cory W CW Roberts Callie M CM Phillips Samantha M SM Nullmeyergh Sarah S Gilmore Samuel P SP Spasojevic Ivan I Corcoran David L DL Young Christopher C CC Ballman Karla V KV Ramakrishna Rohan R Cross Darren A DA Markert James M JM Lim Michael M Gilbert Mark R MR Lesser Glenn J GJ Kwatra Madan M MM
Oncotarget 20200602 22
Epidermal Growth Factor Receptor variant III (EGFRvIII) is an active mutant form of EGFR that drives tumor growth in a subset of glioblastoma (GBM). It occurs in over 20% of GBMs, making it a promising receptor for small molecule targeted therapy. We hypothesize that poor penetration of the blood-brain barrier by previously tested EGFR-tyrosine kinase inhibitors (EGFR-TKIs) such as afateninb, erlotinib, gefitinib, and lapatinib played a role in their limited efficacy. The present study examined ...[more]