Association between cellular HIV-1 DNA level and mortality in HIV-1 infected African adults starting ART with high CD4 counts.

ABSTRACT:

Background

High HIV-1 DNA levels in peripheral blood mononuclear cells (PBMC) were associated with a higher risk of severe morbidity and a faster decline in CD4 count in ART-naive patients. We report the association between HIV-1 DNA and mortality in HIV-infected adults in a trial of early ART in West Africa.

Methods

In the Temprano trial, HIV-infected adults were randomly assigned to start ART immediately or defer ART. After trial termination, HIV-1 DNA was measured in whole blood samples frozen at baseline. We analyzed the association between baseline PBMC HIV-1 DNA and long-term mortality.

Findings

2019 patients were followed for 9253 patient-years (median 4.9 years). At baseline, the median CD4 count was 462/mm³ [IQR 368-571], the median plasma HIV-1 RN

SUBMITTER: N'takpe JB 

PROVIDER: S-EPMC7276518 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature