Ontology highlight
ABSTRACT:
SUBMITTER: Zuhra K
PROVIDER: S-EPMC7277093 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Zuhra Karim K Augsburger Fiona F Majtan Tomas T Szabo Csaba C
Biomolecules 20200430 5
Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration pathway, is an important mammalian enzyme in health and disease. Its biochemical functions under physiological conditions include the metabolism of homocysteine (a cytotoxic molecule and cardiovascular risk factor) and the generation of hydrogen sulfide (H<sub>2</sub>S), a gaseous biological mediator with multiple regulatory roles in the vascular, nervous, and immune system. CBS is up-regulated in severa ...[more]