Ontology highlight
ABSTRACT:
SUBMITTER: Wilson DT
PROVIDER: S-EPMC7277881 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Wilson David T DT Bansal Paramjit S PS Carter David A DA Vetter Irina I Nicke Annette A Dutertre Sébastien S Daly Norelle L NL
Biomedicines 20200520 5
Conopeptides belonging to the A-superfamily from the venomous molluscs, <i>Conus</i>, are typically α-conotoxins. The α-conotoxins are of interest as therapeutic leads and pharmacological tools due to their selectivity and potency at nicotinic acetylcholine receptor (nAChR) subtypes. Structurally, the α-conotoxins have a consensus fold containing two conserved disulfide bonds that define the two-loop framework and brace a helical region. Here we report on a novel α-conotoxin Pl168, identified fr ...[more]