Ontology highlight
ABSTRACT:
SUBMITTER: Wu CC
PROVIDER: S-EPMC7278561 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Wu Cheng-Chun CC Jin Lee-Way LW Wang I-Fang IF Wei Wei-Yen WY Ho Pei-Chuan PC Liu Yu-Chih YC Tsai Kuen-Jer KJ
EMBO molecular medicine 20200525 6
TAR DNA-binding protein 43 (TDP-43) has been implicated in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-TDP) and amyotrophic lateral sclerosis. Histone deacetylase 1 (HDAC1) is involved in DNA repair and neuroprotection in numerous neurodegenerative diseases. However, the pathological mechanisms of FTLD-TDP underlying TDP-43 proteinopathies are unclear, and the role of HDAC1 is also poorly understood. Here, we found that aberrant cell cycle activity and DNA damage a ...[more]