Ontology highlight
ABSTRACT:
SUBMITTER: Mijatovic S
PROVIDER: S-EPMC7278755 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Mijatović Sanja S Savić-Radojević Ana A Plješa-Ercegovac Marija M Simić Tatjana T Nicoletti Ferdinando F Maksimović-Ivanić Danijela D
Antioxidants (Basel, Switzerland) 20200430 5
Disturbed redox homeostasis represents a hallmark of cancer phenotypes, affecting cellular metabolism and redox signaling. Since reactive oxygen and nitrogen species (ROS/RNS) are involved in regulation of proliferation and apoptosis, they may play a double-faced role in cancer, entailing protumorigenic and tumor-suppressing effects in early and later stages, respectively. In addition, ROS and RNS impact the activity and communication of all tumor constituents, mediating their reprogramming from ...[more]