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Polyphenols with Anti-Amyloid ? Aggregation Show Potential Risk of Toxicity Via Pro-Oxidant Properties.

ABSTRACT: Alzheimer's disease (AD) is the most common form of dementia among older people. Amyloid ? (A?) aggregation has been the focus for a therapeutic target for the treatment of AD. Naturally occurring polyphenols have an inhibitory effect on A? aggregation and have attracted a lot of attention for the development of treatment strategies which could mitigate the symptoms of AD. However, considerable evidence has shown that the pro-oxidant mechanisms of polyphenols could have a deleterious effect. Our group has established an assay system to evaluate the pro-oxidant characteristics of chemical compounds, based on their reactivity with DNA. In this review, we have summarized the anti-A? aggregation and pro-oxidant properties of polyphenols. These findings could contribute to understanding the mechanism underlying the potential risk of polyphenols. We would like to emphasize the importance of assessing the pro-oxidant properties of polyphenols from a safety point of view.

SUBMITTER: Kobayashi H 

PROVIDER: S-EPMC7279003 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Polyphenols with Anti-Amyloid β Aggregation Show Potential Risk of Toxicity Via Pro-Oxidant Properties.

Kobayashi Hatasu H   Murata Mariko M   Kawanishi Shosuke S   Oikawa Shinji S  

International journal of molecular sciences 20200518 10

Alzheimer's disease (AD) is the most common form of dementia among older people. Amyloid β (Aβ) aggregation has been the focus for a therapeutic target for the treatment of AD. Naturally occurring polyphenols have an inhibitory effect on Aβ aggregation and have attracted a lot of attention for the development of treatment strategies which could mitigate the symptoms of AD. However, considerable evidence has shown that the pro-oxidant mechanisms of polyphenols could have a deleterious effect. Our  ...[more]

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