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Dynamic Changes of Heart Failure Biomarkers in Response to Parabolic Flight.


ABSTRACT: BACKGROUND:we aimed at investigating the influence of weightlessness and hypergravity by means of parabolic flight on the levels of the heart failure biomarkers H-FABP, sST2, IL-33, GDF-15, suPAR and Fetuin-A. METHODS:14 healthy volunteers (males: eight; mean age: 28.9) undergoing 31 short-term phases of weightlessness and hypergravity were included. At different time points (baseline, 1 h/24 h after parabolic flight), venous blood was drawn and analyzed by the use of ELISA. RESULTS:sST2 evidenced a significant decrease 24 h after parabolic flight (baseline vs. 24, p = 0.009; 1 h vs. 24 h, p = 0.004). A similar finding was observed for GDF-15 (baseline vs. 24 h, p = 0.002; 1 h vs. 24 h, p = 0.025). The suPAR showed a significant decrease 24 h after parabolic flight (baseline vs. 24 h, p = 0.1726; 1 h vs. 24 h, p = 0.009). Fetuin-A showed a significant increase at 1 h and 24 h after parabolic flight (baseline vs. 24 h, p = 0.007; 1 h vs. 24 h, p = 0.04). H-FABP and IL-33 showed no significant differences at all time points. CONCLUSION:Our results suggest a reduction in cardiac stress induced by exposure to gravitational changes. Moreover, our findings indicate an influence of gravitational changes on proliferative processes and calcium homeostasis.

SUBMITTER: Jirak P 

PROVIDER: S-EPMC7279017 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Dynamic Changes of Heart Failure Biomarkers in Response to Parabolic Flight.

Jirak Peter P   Wernly Bernhard B   Lichtenauer Michael M   Lichtenauer Michael M   Paar Vera V   Franz Marcus M   Knost Thorben T   Abusamrah Thaer T   Kelm Malte M   Muessig Johanna M JM   Bimpong-Buta Nana-Yaw NY   Jung Christian C  

International journal of molecular sciences 20200514 10


<h4>Background</h4>we aimed at investigating the influence of weightlessness and hypergravity by means of parabolic flight on the levels of the heart failure biomarkers H-FABP, sST2, IL-33, GDF-15, suPAR and Fetuin-A.<h4>Methods</h4>14 healthy volunteers (males: eight; mean age: 28.9) undergoing 31 short-term phases of weightlessness and hypergravity were included. At different time points (baseline, 1 h/24 h after parabolic flight), venous blood was drawn and analyzed by the use of ELISA.<h4>Re  ...[more]

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