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Outcome measurement in functional neurological disorder: a systematic review and recommendations.

ABSTRACT: OBJECTIVES:We aimed to identify existing outcome measures for functional neurological disorder (FND), to inform the development of recommendations and to guide future research on FND outcomes. METHODS:A systematic review was conducted to identify existing FND-specific outcome measures and the most common measurement domains and measures in previous treatment studies. Searches of Embase, MEDLINE and PsycINFO were conducted between January 1965 and June 2019. The findings were discussed during two international meetings of the FND-Core Outcome Measures group. RESULTS:Five FND-specific measures were identified-three clinician-rated and two patient-rated-but their measurement properties have not been rigorously evaluated. No single measure was identified for use across the range of FND symptoms in adults. Across randomised controlled trials (k=40) and observational treatment studies (k=40), outcome measures most often assessed core FND symptom change. Other domains measured commonly were additional physical and psychological symptoms, life impact (ie, quality of life, disability and general functioning) and health economics/cost-utility (eg, healthcare resource use and quality-adjusted life years). CONCLUSIONS:There are few well-validated FND-specific outcome measures. Thus, at present, we recommend that existing outcome measures, known to be reliable, valid and responsive in FND or closely related populations, are used to capture key outcome domains. Increased consistency in outcome measurement will facilitate comparison of treatment effects across FND symptom types and treatment modalities. Future work needs to more rigorously validate outcome measures used in this population.

SUBMITTER: Pick S

PROVIDER: S-EPMC7279198 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Outcome measurement in functional neurological disorder: a systematic review and recommendations.

Pick Susannah S Anderson David G DG Asadi-Pooya Ali A AA Aybek Selma S Baslet Gaston G Bloem Bastiaan R BR Bradley-Westguard Abigail A Brown Richard J RJ Carson Alan J AJ Chalder Trudie T Damianova Maria M David Anthony S AS Edwards Mark J MJ Epstein Steven A SA Espay Alberto J AJ Garcin Béatrice B Goldstein Laura H LH Hallett Mark M Jankovic Joseph J Joyce Eileen M EM Kanaan Richard A RA Keynejad Roxanne C RC Kozlowska Kasia K LaFaver Kathrin K LaFrance W Curt WC Lang Anthony E AE Lehn Alex A Lehn Alex A Lidstone Sarah S Maurer Carine W CW Mildon Bridget B Morgante Francesca F Myers Lorna L Nicholson Clare C Nielsen Glenn G Perez David L DL Popkirov Stoyan S Reuber Markus M Rommelfanger Karen S KS Schwingenshuh Petra P Serranova Tereza T Shotbolt Paul P Stebbins Glenn T GT Stone Jon J Tijssen Marina Aj MA Tinazzi Michele M Nicholson Timothy R TR

Journal of neurology, neurosurgery, and psychiatry 20200228 6

<h4>Objectives</h4>We aimed to identify existing outcome measures for functional neurological disorder (FND), to inform the development of recommendations and to guide future research on FND outcomes.<h4>Methods</h4>A systematic review was conducted to identify existing FND-specific outcome measures and the most common measurement domains and measures in previous treatment studies. Searches of Embase, MEDLINE and PsycINFO were conducted between January 1965 and June 2019. The findings were discu ...[more]

PMID: 32111637

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Project description:Several measurement tools commonly used in face-to-face neurological rehabilitation have been used in telerehabilitation. However, it is not known whether these tools have adequate measurement properties and clinical utility. This systematic review aims to investigate the measurement properties and the clinical utility of measurement tools used in telerehabilitation in individuals with neurological diseases. A systematic review to investigate the measurement properties and clinical utility of measurement tools used in telerehabilitation in individuals with neurological conditions will be conducted. This systematic review will follow the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) statement. this systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) on 28 May 2021 (registration number: CRD42021257662). Electronic searches will be performed in following databases: Medical Literature Analysis and Retrieval System Online (MEDLINE Ovid), Excerpta Medica Database (Embase Classic + Embase Ovid), Physiotherapy Evidence Database (PEDro), Scientific Electronic Library Online (Scielo), and Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). Two trained independent reviewers will select the studies according to the inclusion criteria, and will also extract the data, evaluate the clinical utility and methodological quality. The relevant data such as design, participants, settings, and mode of administration, measurement properties, and clinical utility will be summarized. Disagreements between reviewers will be resolved by consensus or by the decision of a third independent reviewer. Hand searches of other relevant studies will be employed. The COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) checklist and the clinical utility scale will be used to assess the methodological quality and clinical utility of these tools, respectively. This systematic review will provide information regarding the measurement properties and the clinical utility of the measurement tools used in neurological telerehabilitation. This information will be useful to assist health professionals in choosing adequate measurement tools and planning new research studies.

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Outcome measurement in functional neurological disorder: a systematic review and recommendations.

Publications

Outcome measurement in functional neurological disorder: a systematic review and recommendations.

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