Ontology highlight
ABSTRACT:
SUBMITTER: Lazewska D
PROVIDER: S-EPMC7279487 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Łażewska Dorota D Olejarz-Maciej Agnieszka A Reiner David D Kaleta Maria M Latacz Gniewomir G Zygmunt Małgorzata M Doroz-Płonka Agata A Karcz Tadeusz T Frank Annika A Stark Holger H Kieć-Kononowicz Katarzyna K
International journal of molecular sciences 20200512 10
Dual target ligands are a promising concept for the treatment of Parkinson's disease (PD). A combination of monoamine oxidase B (MAO B) inhibition with histamine H<sub>3</sub> receptor (H<sub>3</sub>R) antagonism could have positive effects on dopamine regulation. Thus, a series of twenty-seven 4-<i>tert</i>-butylphenoxyalkoxyamines were designed as potential dual-target ligands for PD based on the structure of 1-(3-(4-<i>tert</i>-butylphenoxy)propyl)piperidine (<b>DL76</b>). Probed modification ...[more]