Ontology highlight
ABSTRACT:
SUBMITTER: Manzella L
PROVIDER: S-EPMC7279803 | biostudies-literature | 2020 May-Jun
REPOSITORIES: biostudies-literature
In vivo (Athens, Greece) 20200501 3
<h4>Background/aim</h4>The Philadelphia chromosome is considered the hallmark of chronic myeloid leukemia (CML). However, although most patients with CML are diagnosed with the e13a2 or e14a2 breakpoint cluster region (BCR)-Abelson 1 (ABL1) fusion transcripts, about 5% of them carry rare BCR-ABL1 fusion transcripts, such as e19a2, e8a2, e13a3, e14a3, e1a3 and e6a2. In particular, the e6a2 fusion transcript has been associated with clinically aggressive disease frequently presenting in accelerate ...[more]