Expression and Prognostic Significance of CDK8 and ?-Catenin in Hepatocellular Carcinoma.

ABSTRACT: BACKGROUND/AIM:Cyclin-dependent kinase 8 (CDK8) is known to play an important role in the early development and progression of various cancers, and the Wnt/?-catenin pathway is also involved in cancer progression. Nevertheless, relatively little is known about the regulatory mechanisms of the ?-catenin pathway in hepatocellular carcinoma (HCC). MATERIALS AND METHODS:The complete clinicopathological features of 122 pairs of HCC and adjacent non-tumor tissues were analyzed and immunohistochemistry was used to detect the aberrant expression of CDK8 and ?-catenin. Overall survival rates (OSRs) were evaluated using the Kaplan-Meier method and Cox multivariate analysis was used to assess the prognostic values. RESULTS:Aberrant expression of nuclear ?-catenin and CDK8 are independent prognostic variables that negatively affect the OSR. The aberrant expression of CDK8 was associated with the dysregulated expression of ?-catenin and correlated with a poor prognosis. CONCLUSION:Inhibition of CDK8 and/or nuclear ?-catenin expression pattern could serve as a promising therapeutic strategy for the treatment of HCC.

SUBMITTER: Han SI 

PROVIDER: S-EPMC7279855 | biostudies-literature | 2020 May-Jun

REPOSITORIES: biostudies-literature